Betting On The Sweet 16: East Region Odds, Trends, and Picks

• The No. 1 seed Michigan Wolverines +150 odds are the shortest of any teams to win the East Region.
• The No. 2 seed Alabama Crimson Tide are 6.5-point favorites over the UCLA Bruins in the Sweet 16.
• The (4) Florida State Seminoles are +115 moneyline underdogs against the (1) Michigan Wolverines who have -135 odds to win in the Sweet 16.

INDIANAPOLIS – The 2021 NCAA Men’s Basketball Tournament leading up to the Sweet 16 round this weekend has lived up to the hype as there have been plenty of upsets and close games.

The East Region of the NCAA Tournament is anchored by the No. 1 seed Michigan Wolverines who have shown why they earned the top seed in a COVID-19 altered college basketball betting season.

The East is one of the deeper regions with three of the top four seeds still alive in the Sweet 16 and all could make a run to the national title game. Who will represent the East Region in the Final Four remains to be seen but Bovada has betting odds available on each of the four teams.

Odds To Win East Region 2021 NCAA Tournament

• Michigan (#1) +150
• Alabama (#2) +180
• Florida State (#4) +325
• UCLA (#11) +700

For March Madness bettors looking to bet on the East Region games in the Sweet 16 there are two matchups to choose from as the No. 4 seed Florida State Seminoles take on the No. 1 seed Michigan Wolverines and the No. 11 seed UCLA Bruins face the No. 2 seed Alabama Crimson Tide.

Each matchup presents a unique opportunity for bettors to beat the bookie.

(4) Florida State Seminoles vs. (1) Michigan Wolverines Odds @ 5 p.m. EST

• Moneyline: Seminoles (+115) vs. Wolverines (-135)
• Spread: Michigan (-2.5)
• O/U: 143.5

Florida State Betting Trends

• The Seminoles have a 7-3 SU record in their last 10 games.
• The total has gone over in 12 of Florida State’s last 18 games.

Michigan Betting Trends

• Michigan has a 14-6 record ATS in their last 20 games.
• The total has gone under in 12 of Michigan’s last 17 games.

Winner: Seminoles (+115). The top seed Michigan Wolverines face their toughest opponent yet in the 4-seed Florida State Seminoles. Florida State has the size that can make this a tough game for the Wolverines and explains why oddsmakers have such a narrow spread at -2.5 points. Bettors shouldn’t hesitate to take the Seminoles SU (+115) in this Sweet 16 matchup. These two teams are evenly matched and even if not wanting to take the moneyline here keep in mind that FSU is 3-0 ATS in their last three meetings against Michigan.

(11) UCLA Bruins vs. (2) Alabama Crimson Tide (-6.5) Odds @ 7:15 p.m. EST

• Spread: Alabama (-6.5)
• Moneyline: UCLA (+220) vs. Alabama (-270)
• O/U: 143.5

UCLA Betting Trends

• The Bruins are 4-1 ATS in their last five games.
• UCLA’s two NCAA Tournament games have seen the total go under.

Alabama Betting Trends

• The total has gone under in six of Alabama’s last nine games.
• The Crimson Tide have a 5-2 record ATS in their last seven games.

Winner: Alabama (-6.5). The (2) Alabama Crimson Tide face the (11) UCLA Bruins with an Elite 8 berth on the line. The Crimson Tide are favored and rightfully so as they’ve been one of the hottest teams in the country the past few weeks and that momentum will likely carry over into this Sweet 16 matchup. Alabama is ranked in the top 10 in both Basketball Power Index (BPI) and KenPom rating while UCLA is ranked 22nd in KenPom and 34th in BPI. This game could turn into a blowout as Alabama on both sides of the ball have the advantage over UCLA. Take the Crimson Tide to cover the spread here as they have a 5-2 record ATS including a six-point cover in the last round.